Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. Bronchi. Assign inside 3-4 times a day. As an antiplatelet drug prescribed for acute myocardial infarction, ischemic stroke. Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. Side effects of NSAIDs Gastrointestinal tract. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Bradykinin, in addition, stimulates sensory nerve endings (pain mediator). Prostaglandin E2, in addition, causes an line in temperature (effect on line centers in the hypothalamus) and stimulates line reduction of the myometrium. Especially pronounced ulcerogenic effect in inhibiting TSOG1. Methyl salicylate - a liquid with a characteristic odor, which at the local of line application of analgesic and has anti-inflammatory effect. Salicylates. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases. Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe Hydroxyeicosatetraenoic Acid particularly when line ankylosing spondylitis and gout. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). TSOG1 is a constant (base), cyclooxygenase; level TSOG2 significantly increased only during inflammation. In small doses, aspirin line platelet aggregation. Piroxicam and meloxicam (Movalis) here Effective protivovospa-inflammatory long-acting, take 1 once a day for rheumatoid arthritis, spondylitis, acute attacks of gout. Normal NSAIDs do not reduce temperature and act as antipyretics for fever only. Applied in inflammatory diseases niyah joints, and spine (spondylitis), myositis, neuralgia, migraine attacks, algodismenoree and gout. Fenoprofen, flurbiprofen are similar to ibuprofen on the properties and the Application of. Rofecoxib use 1 time well developed and well nourished day for the same reasons-wells, as well as toothache, pain after operations at algodismenoree. Prostaglandin F2a stimulates spermatogenesis and increases the efficiency of sperm-ak line . There are NSAIDs, which inhibit mainly TSOG2 - celecoxib, rofecoxib. Derivatives of propionic acid. Diklofenaknatry derivatives of propionic acid Ibuprofen Naproxen Piroxicam Meloxicam Oksikamy Year to Date of the above funds have basically three properties: anti-inflammatory, analgesic and antipyretic. Kidney. Myometrium. Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and osteoarthritis. FAT dilates blood vessels, increases vascular permeability by reducing the em-blood pressure, increases the aggregation platelets and bronchial tone. Spermatogenesis. In the application of NSAIDs, line nausea, discomfort in the same-ludka. Therefore, in patients with bronchial asthma acetylsalicylic acid (aspirin) can provoke bronchospasm ("Al-pirinovaya asthma"). Prostaglandins E2 and 12 have a line action: reduce the secretion of HC1, increase mucus secretion line the FNL, increase the resistance of cells of gastric mucosa and dvenadtsatiper-stnoy guts to damaging factors, improve mucosal blood flow. To reduce the ulcerogenic effect of NSAIDs combining them line drug-mi gastroprotective prostaglandins (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. Therefore, NSAIDs reduce the co-kratitelnuyu activity of the myometrium and may slow onset of labor. Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system).
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